Анализ технических средств для измерения параметров кривизны скважины

Магистерская диссертация включает 109 страниц текстового материала, 21 рисунок, 12 таблиц, 45 источников, 4 приложения. Объект исследования: Телеметрическое оборудование для проведения измерений параметров кривизны скважины. Цель работы: разработка методики выбора телеметрической системы дляконкретно заданных геолого-технических условий. Результаты исследования: Основным результатом исследовательской работы является разработка методики выбора телеметрической системы для различных геолого технологических условий. Методы проведения исследования: Был проведен сбор данных практического использования различных телеметрических систем и по результатам проведенного анализа приведены рекомендации по выбору подходящего типа оборудования для различных геолого-технологических условий.Object of research: M/LWD telemetry systems. Results of research: The main result of the research work is the development of a methodology for selecting a telemetry system for various geological and technical conditions. Methods of conducting the research: Oil filed data was collected systems and as a result of a comparative analysis of the data obtained in a table of recommendations

The chemokine receptor CXCR3 limits injury after acute toxic liver damage

Although acute liver failure is a rare disease, its presence is associated with high morbidity and mortality in affected patients. While a contribution of the immune system to the outcome of toxic liver failure is anticipated, functionally relevant immune cell receptors for liver cell damage need to be better defined. We here investigate the relevance of the chemokine receptor CXCR3, which is important for hepatic immune cell infiltration, in a model of experimental acute liver failure. Liver injury was induced by a single intraperitoneal injection of carbon tetrachloride (CCl 4) in CXCR3 -/-, CCR1 -/-, CCR5 -/- and wild-type mice. In this model, CXCR3 -/- mice displayed augmented liver damage compared with all other mouse strains as assessed by liver histology and serum transaminases 24 and 72 h after injury. Phenotypically, CXCR3 -/- mice had significantly reduced intrahepatic NK and NKT cells after injury at all investigated time points (all P≤0.05), but strongly elevated expression levels of IL1-Β, TNF-α and IFN-γ. In line with a functional role of innate immune cells, wild-type mice depleted for NK cells with an anti-ASIALO GM1 antibody before liver injury also displayed increased liver injury after CCl 4 challenge. CXCR3 -/- and NK cell-depleted mice show reduced apoptotic liver cells (TUNEL assay), but more necrotic hepatocytes. Functionally, the augmented liver cell necrosis in CXCR3 -/- and NK cell-depleted mice was associated with increased expression of high mobility group 1 (HMGB1) protein and a consecutive enhanced infiltration of neutrophils into the liver. In conclusion, the results demonstrate a primarily unexpected beneficial role of CXCR3 in acute toxic liver injury. These findings should be taken into account when planning trials with CXCR3 antagonists. © 2012 USCAP, Inc All rights reserved